Interaction network and enrichment analysis of genes upregulated following Estradiol treatment
Canned Analysis
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General Information
AccessionDCA00035914
TitleInteraction network and enrichment analysis of genes upregulated following Estradiol treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Estradiol treated cells and untreated control cells in the Endothelial cells (cultured umbilical vein endothelial cells) - treated with 1 nmol/L estradiol for 24 hours cell type.
Analysis URLhttp://genemania.org/#/search/human/ND2|RPL36|CFL1|MMP1|HSPB1|FLNA|ITGA5|COL4A2|SLC25A6|TGFB1I1|DCAF6|PFN1|IGFBP4|HLA-B|GABARAP|ACTG1|HLA-C|PHB2|RNASEK|PKD1P1|EIF3CL|HSP90AB1|CRIP2|HLA-A|HSPG2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3394
Cell TypeEndothelial cells (cultured umbilical vein endothelial cells) - treated with 1 nmol/L estradiol for 24 hours
Drug NameEstradiol
DrugBank IDDB00783
Organismhuman
PubChem CID5757
SMILES IDCC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM418126, GSM418127, GSM418128
Perturbed SamplesGSM418129, GSM418130, GSM418131
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE16683
Gene Expression Omnibus
Endothelial cell response to estradiol in vitro
7
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