Interaction network and enrichment analysis of genes downregulated following 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) treatment
Canned Analysis
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General Information
AccessionDCA00035951
TitleInteraction network and enrichment analysis of genes downregulated following 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) treated cells and untreated control cells in the HL-60 cells cell type.
Analysis URLhttp://genemania.org/#/search/human/PRG2|RPL12|GAPDH|EEF1A1P9|RPL19|RPL6|EEF1A1|RPL11|MYC|RPL4|ENO1|LDHB|YBX1|PHB2|MIF|EEF1G|UBC|APEX1|RPS5|RPL30|ALDOA|RPLP0P6|PFN1|EIF3E|RPS16
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:3426
Cell TypeHL-60 cells
Drug Name2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)
Organismhuman
PubChem CID15625
SMILES IDC1=C2C(=CC(=C1Cl)Cl)OC3=CC(=C(C=C3O2)Cl)Cl
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM405501, GSM405502
Perturbed SamplesGSM405499, GSM405500
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE16160
Gene Expression Omnibus
Expression data of HL-60 leukemia cells after treatment with Curcumin and TCDD
14
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