Interaction network and enrichment analysis of genes downregulated following Quercetin treatment
Canned Analysis
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General Information
AccessionDCA00035981
TitleInteraction network and enrichment analysis of genes downregulated following Quercetin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Quercetin treated cells and untreated control cells in the liver cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Scd1|Cyp2c29|Cyp2c70|Elovl5|G0s2|Cyp3a25|Aldob|Rnf125|Mup19|Elovl3|Cps1|G6pc|Tat|Cyp3a11|Khk|Hsd3b5|C730049O14Rik|Mbl2|Actb|Calr|LOC100048117|Pzp|Inmt|Nr0b2|Ugt2b1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:3438
Cell Typeliver
Drug NameQuercetin
DrugBank IDDB04216
Organismmouse
SMILES IDOc1cc(O)c2c(c1)oc(c(c2=O)O)c1ccc(c(c1)O)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM935660, GSM935661, GSM935662, GSM935663, GSM935664, GSM935665
Perturbed SamplesGSM935678, GSM935679, GSM935680, GSM935681, GSM935682, GSM935683
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE38136
Gene Expression Omnibus
Hepatic gene expression in BALB/c mice fed a quercetin diet
14
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