Interaction network and enrichment analysis of genes downregulated following Calcitonin treatment
Canned Analysis
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General Information
AccessionDCA00035995
TitleInteraction network and enrichment analysis of genes downregulated following Calcitonin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Calcitonin treated cells and untreated control cells in the osteoclasts (wild type) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/LOC433053|Hmox1|Efemp1|Cd200|Mid1ip1|Ank|Emc2|Atp6v0d2|Pf4|Tma7|Psenen|Sptssa|LOC100503721|Cyth4|Ctsb|Blnk|Atp6v1c1|Mettl9|Lipa|A730098P11Rik|Alas1|Npc2|Hn1|Cd5l|Fnbp1l
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:3446
Cell Typeosteoclasts (wild type)
Drug NameCalcitonin
Organismmouse
PubChem CID16132288
SMILES IDCCC(C)C(C(=O)NCC(=O)NC(C(C)C)C(=O)NCC(=O)NC(C)C(=O)N1CCCC1C(=O)N)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(CCC(=O)N)NC(=O)C2CCCN2C(=O)C(CC3=CC=CC=C3)NC(=O)C(C(C)O)NC(=O)C(CC4=CN=CN4)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CC6=CC=CC=C6)NC(=O)C(CC(
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1487524, GSM1487525, GSM1487526
Perturbed SamplesGSM1487527, GSM1487528, GSM1487529
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE60761
Gene Expression Omnibus
Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts
21
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