Interaction network and enrichment analysis of genes downregulated following Vitamin e treatment
Canned Analysis
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General Information
AccessionDCA00036053
TitleInteraction network and enrichment analysis of genes downregulated following Vitamin e treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Vitamin e treated cells and untreated control cells in the Brains of aged (30-month-old) B6C3F1 animals fed a diet containing alpha-tocopherol cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Rps27a|Ctxn1|Rheb|Ppia|Pebp1|Nrgn|Mt3|Rpl38|Rps11|Tma7|Snhg11|Rplp2|Thy1|Chchd2|Chchd10|Basp1|Rpl4|Rps28|Chst1|Tuba1b|Cox6b1|Pisd|Gm13826|Stmn3|Chgb
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3477
Cell TypeBrains of aged (30-month-old) B6C3F1 animals fed a diet containing alpha-tocopherol
Drug NameVitamin e
DrugBank IDDB00163
Organismmouse
PubChem CID14985
SMILES IDCC1=C(C(=C2CCC(OC2=C1C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM201796, GSM201797, GSM201799, GSM201801, GSM201802
Perturbed SamplesGSM201804, GSM201805, GSM201806, GSM201808, GSM201809
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE8150
Gene Expression Omnibus
Vitamin E supplementation effect on aged brain
7
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