Interaction network and enrichment analysis of genes downregulated following Vitamin e treatment
Canned Analysis
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General Information
AccessionDCA00036055
TitleInteraction network and enrichment analysis of genes downregulated following Vitamin e treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Vitamin e treated cells and untreated control cells in the Hearts of 30-month-old B6C3F1 animals fed a diet supplemented with alpha-tocopherol cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Rps2|Laptm4a|Fhl2|Alas1|Hbb-b2|Rplp0|Actg1|Ctnnb1|Prkar1a|Ldha|Rpl8|Gsn|Egln1|Snx3|Tuba1b|Ndufb3|Sdhc|Sdhd|B2m|Acta1|Rpl13|Cd99|Hopx|Ppif|Coq10a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3478
Cell TypeHearts of 30-month-old B6C3F1 animals fed a diet supplemented with alpha-tocopherol
Drug NameVitamin e
DrugBank IDDB00163
Organismmouse
PubChem CID14985
SMILES IDCC1=C(C(=C2CCC(OC2=C1C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM201741, GSM201753, GSM201767, GSM201768, GSM201770
Perturbed SamplesGSM201772, GSM201773, GSM201775, GSM201777, GSM201778
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE8146
Gene Expression Omnibus
Vitamin E supplementation effect on aged heart
7
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