Interaction network and enrichment analysis of genes upregulated following Resveratrol treatment
Canned Analysis
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General Information
AccessionDCA00036082
TitleInteraction network and enrichment analysis of genes upregulated following Resveratrol treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between Resveratrol treated cells and untreated control cells in the MCF7 cells cell type.
Analysis URLhttp://genemania.org/#/search/human/SAT1|GDF15|RND1|FTL|FTH1|NEU1|SQSTM1|TFF1|PGD|P4HB|SDC4|RN7SL2|NFKBIA|TNFRSF12A|HSPA5|SNHG3|ACTG1|LDLR|UBC|INSIG1|RPPH1|PLK2|JUNB|ZNF217|GRN
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:3501
Cell TypeMCF7 cells
Drug NameResveratrol
DrugBank IDDB02709
Organismhuman
SMILES IDOc1ccc(cc1)/C=C/c1cc(O)cc(c1)O
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM624008, GSM624009, GSM624010
Perturbed SamplesGSM624014, GSM624015, GSM624016
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE25412
Gene Expression Omnibus
Resveratrol induces downregulation of DNA repair genes in MCF7 human breast cancer cells.
14
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