Interaction network and enrichment analysis of genes downregulated following Vitamin c treatment
Canned Analysis
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General Information
AccessionDCA00036091
TitleInteraction network and enrichment analysis of genes downregulated following Vitamin c treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Vitamin c treated cells and untreated control cells in the Oct4-GiP mouse embryonic stem (ES) cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Eno1b|Aldoa|Pgk1|Crip1|Eno1|Hist1h2bm|Pkm|Rmrp|Fabp3|Ifitm1|Ldha|Rn7sk|Rny3|Ost4|Apoe|Slc2a1|Mif|Erdr1|Apoc1|Plp2|Hexb|Hist1h2br|Ndufa4l2|Igfbp2|Hist1h2bn
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:3506
Cell TypeOct4-GiP mouse embryonic stem (ES) cells
Drug NameVitamin c
DrugBank IDDB00126
Organismmouse
SMILES IDOC[C@@H]([C@H]1OC(=O)C(=C1O)O)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1128601, GSM1128602, GSM1128603
Perturbed SamplesGSM1128604, GSM1128605, GSM1128606
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE46319
Gene Expression Omnibus
Vitamin C induces Tet-dependent DNA demethylation in ES cells to promote a blastocyst-like methylome [Affymetrix]
7
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