Interaction network and enrichment analysis of genes downregulated following Vitamin c treatment
Canned Analysis
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General Information
AccessionDCA00036103
TitleInteraction network and enrichment analysis of genes downregulated following Vitamin c treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Vitamin c treated cells and untreated control cells in the mouse embryonic fibroblast cells (MEF cells) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Igfbp3|H19|Timp3|Col1a2|Malat1|Fstl1|Sparc|Fbln5|Hsp90b1|Ctsl|Tnc|Mir675|Eno1b|Thbs1|Gapdh|Fn1|Tmem59|Cdh11|Btg1|Pou5f1|Itgav|Fbln2|Dpysl3|Rn28s1|Pam
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:3512
Cell Typemouse embryonic fibroblast cells (MEF cells)
Drug NameVitamin c
DrugBank IDDB00126
Organismmouse
SMILES IDOC[C@@H]([C@H]1OC(=O)C(=C1O)O)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM480923, GSM480924, GSM480925, GSM480926, GSM480927, GSM480928
Perturbed SamplesGSM480929, GSM480930, GSM480931, GSM480932, GSM480933, GSM480934
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE19379
Gene Expression Omnibus
DNA microarrays time course of SKO-infected MEFs and MaF pre-iPSCs treated with Vc
14
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