Interaction network and enrichment analysis of genes downregulated following Vitamin e treatment
Canned Analysis
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General Information
AccessionDCA00036107
TitleInteraction network and enrichment analysis of genes downregulated following Vitamin e treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Vitamin e treated cells and untreated control cells in the aorta cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Mup19|Cfd|Alb|Apoe|Serpina1c|Adipoq|Cyp2e1|C3|Gm4076|Gpx3|Cyc1|Ech1|Lpl|Ttr|Apoc1|Apoa2|Serpina1b|Bnip3|Scgb1a1|Fmo1|Rpl39-ps|Car3|Sdhb|Apoa1|Uqcrc2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDdrug:3515
Cell Typeaorta
Drug NameVitamin e
DrugBank IDDB00163
Organismmouse
PubChem CID14985
SMILES IDCC1=C(C(=C2CCC(OC2=C1C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM478610, GSM478611
Perturbed SamplesGSM1050380, GSM1050381
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE42813
Gene Expression Omnibus
Microarray gene expression profiling of aortic genes of APOE-deficient mice receiving atherosclerosis treatment with the antioxidant vitamin E
7
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