Interaction network and enrichment analysis of genes downregulated following Bisphenol a treatment
Canned Analysis
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General Information
AccessionDCA00036207
TitleInteraction network and enrichment analysis of genes downregulated following Bisphenol a treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Bisphenol a treated cells and untreated control cells in the testicular Sertoli cells - 3 Hours cell type.
Analysis URLhttp://genemania.org/#/search/mouse/S100a11|Gstp1|S100a6|Gm8894|Prdx1|Cox6b1|Cox7a2|Psma2|Dcn|Gm5526|Atp5g3|Anxa5|Zbed5|Skp1a|Bud31|Mif|Tmsb4x|Anxa1|Tmem176b|Cd81|Atp5k|Pomp|Kpna2|Aldh1a1|Ifitm2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3573
Cell Typetesticular Sertoli cells - 3 Hours
Drug NameBisphenol a
Organismmouse
PubChem CID6623
SMILES IDCC(C)(C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM104743, GSM104744
Perturbed SamplesGSM104745, GSM104746
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE4650
Gene Expression Omnibus
Bisphenol A effect on testicular Sertoli cells: time course
21
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