Interaction network and enrichment analysis of genes downregulated following Zinc acetate treatment
Canned Analysis
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General Information
AccessionDCA00036233
TitleInteraction network and enrichment analysis of genes downregulated following Zinc acetate treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Zinc acetate treated cells and untreated control cells in the Ramos B-cell lymphoma line - 25 uM cell type.
Analysis URLhttp://genemania.org/#/search/human/RLIM|SH3KBP1|RPL7A|RPS2|TUBA1C|LDHA|SNHG5|NOP58|IGLC7|BIK|COX3|RPLP0|RPL41|PTMA|LOC728825|PABPC3|RPS6|GAPDH|RPS8|RAN|DCK|RPL19|SEC31B|UBA52|IARS
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3589
Cell TypeRamos B-cell lymphoma line - 25 uM
Drug NameZinc acetate
Organismhuman
PubChem CID11192
SMILES IDCC(=O)[O-].CC(=O)[O-].[Zn+2]
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM64867, GSM64868, GSM64869
Perturbed SamplesGSM64870, GSM64871, GSM64872
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2964
Gene Expression Omnibus
Motexafin gadolinium and zinc effect on Ramos B-cell lymphoma line
21
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