Interaction network and enrichment analysis of genes downregulated following Leptin treatment
Canned Analysis
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General Information
AccessionDCA00036239
TitleInteraction network and enrichment analysis of genes downregulated following Leptin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Leptin treated cells and untreated control cells in the Gallbladders (from leptin-deficient obese females following daily treatment with 5 ug/g recombinant leptin for 4 weeks) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Mt2|Scd1|Aldob|E430024C06Rik|Apoa4|Slc25a47|Krt8|Mmp7|Sgk1|Reg1|Adh1|Cyp2c29|Ctgf|Gm3776|Gapdh|Plin2|Gnmt|Ndufa4|LOC100048117|Tnfrsf12a|Gm4076|1200016E24Rik|Apoc3|Actg1|Crip1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3592
Cell TypeGallbladders (from leptin-deficient obese females following daily treatment with 5 ug/g recombinant leptin for 4 weeks)
Drug NameLeptin
DrugBank IDDB05098
Organismmouse
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM74081, GSM74083, GSM74171, GSM74189
Perturbed SamplesGSM74190, GSM74191, GSM74192, GSM74194
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3293
Gene Expression Omnibus
Leptin effect on gallbladder
12
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