Interaction network and enrichment analysis of genes downregulated following 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
Canned Analysis
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General Information
AccessionDCA00036255
TitleInteraction network and enrichment analysis of genes downregulated following 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells and untreated control cells in the 17.5 day fetal hearts - 1.5ug/kg cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Myh6|Fabp3|Gm15772|Tpi1|Rps11|Hk1|Pabpc1|Rpl21|Uqcrh|Atp5a1|Crip2|Rpl34|Mdh2|Gm13826|Tnnc1|Rpl7|Lta4h|Ldha|Eng|Slmap|Nppb|Rplp0|Rps19|Ptma|Tmsb10
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3600
Cell Type17.5 day fetal hearts - 1.5ug/kg
Drug Name2,3,7,8-tetrachlorodibenzo-p-dioxin
Organismmouse
PubChem CID10852289
SMILES IDCC(C)C=CC(=O)ONC(=O)COC1=CC=C(C=C1)[N+](=O)[O-]
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM60894, GSM60895, GSM60896, GSM60897, GSM60902, GSM60903, GSM60906, GSM60907
Perturbed SamplesGSM60898, GSM60901, GSM60904, GSM60908
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2812
Gene Expression Omnibus
2,3,7,8-tetrachlorodibenzo-p-dioxin effect on cardiovascular development
21
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