Interaction network and enrichment analysis of genes downregulated following Progesterone treatment
Canned Analysis
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General Information
AccessionDCA00036379
TitleInteraction network and enrichment analysis of genes downregulated following Progesterone treatment
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Progesterone treated cells and untreated control cells in the Uterus - 6 Hours cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Cd24a|Gabarapl1|Cyb5r3|Ifitm3|Gsto1|Pnrc1|Ccl21b|Gdpd3|Igkv6-23|Lum|BC094435|C3|Rpl36|Gm10845|Calb1|Cfd|Car3|Sparcl1|Rarres2|Gm19353|Itm2b|Tmem176b|Car2|Akr1a1|Igfbp3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3686
Cell TypeUterus - 6 Hours
Drug NameProgesterone
DrugBank IDDB00396
Organismmouse
PubChem CID5994
SMILES IDCC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM3053, GSM3058
Perturbed SamplesGSM3056, GSM3059
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE6440
Gene Expression Omnibus
Progesterone effects on uterus time course
7
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