Interaction network and enrichment analysis of genes downregulated in PRKAG3 Mutation - R225Q transgenic mutants
Canned Analysis
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General Information
AccessionDCA00036465
TitleInteraction network and enrichment analysis of genes downregulated in PRKAG3 Mutation - R225Q transgenic mutants
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between PRKAG3 Mutation - R225Q transgenic mutants cells and control cells in the Skeletal muscle (gastrocnemius) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Amd1|Myh2|Rps2-ps6|Casq1|Rpl4|Rps5|Rps3a2|Cmya5|Pygm|Rplp2|Rps27rt|Rps28|Rpl31|Rps6-ps4|Adipoq|Kxd1|Gm10260|Rpl10|Rplp1|LOC100044627|Ddit4l|Eef1g|Rpl31-ps17|Rps23|Park7
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1034
Cell TypeSkeletal muscle (gastrocnemius)
Gene Symbol (human)PRKAG3
Gene Symbol (mouse)Prkag3
Organismmouse
Perturbation TypeMutation - R225Q transgenic mutants
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM93235, GSM93236, GSM93237, GSM93238, GSM93239, GSM93240
Perturbed SamplesGSM93229, GSM93230, GSM93231, GSM93232, GSM93233, GSM93234
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE4065
Gene Expression Omnibus
AMP-activated protein kinase gamma-3 R225Q mutation effect on skeletal muscle
7
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