Interaction network and enrichment analysis of genes downregulated in ESRRB Mutation - (ERR-beta; NR3B2)
Canned Analysis
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General Information
AccessionDCA00036475
TitleInteraction network and enrichment analysis of genes downregulated in ESRRB Mutation - (ERR-beta; NR3B2)
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between ESRRB Mutation - (ERR-beta; NR3B2) cells and control cells in the Stria vascularis cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Igfbp2|Col2a1|Gjb2|Ptgds|Enpep|Hbb-bs|Apoe|Cdkn1c|Mmp2|Mtch1|Hba-a2|Fstl1|Gm4076|Tbx18|Podxl2|Slc12a2|Gjb6|Aes|Gnb2|Lamp1|Eif3f|Laptm4a|LOC100048117|Dct|Rpl39-ps
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1047
Cell TypeStria vascularis
Gene Symbol (human)ESRRB
Gene Symbol (mouse)Esrrb
Organismmouse
Perturbation TypeMutation - (ERR-beta; NR3B2)
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM209600, GSM209601, GSM209602
Perturbed SamplesGSM209603, GSM209604, GSM209605
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE8434
Gene Expression Omnibus
Estrogen-related receptor beta mutation effect on the stria vascularis
7
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