Interaction network and enrichment analysis of genes downregulated in EP300 KD
Canned Analysis
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General Information
AccessionDCA00036479
TitleInteraction network and enrichment analysis of genes downregulated in EP300 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between EP300 KD cells and control cells in the CD4+CD25+ Treg cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Hbb-bs|Hist1h2ao|Lgals1|Crip1|Hba-a2|Actg1|Tuba1b|S100a4|S100a10|Gm4076|Ccl5|Rps2-ps6|LOC100048117|Rps2|Rpl36a|Cfl1|Rplp2|Foxp3|S100a6|Rps13|Mif|Ldha|Rpl36al|Rpl28|LOC100503055
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1050
Cell TypeCD4+CD25+ Treg
Gene Symbol (human)EP300
Gene Symbol (mouse)Ep300
Organismmouse
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1164170, GSM1164171, GSM1164172
Perturbed SamplesGSM1164167, GSM1164168, GSM1164169
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE47989
Gene Expression Omnibus
Inhibition of p300 impairs Foxp3+ T-regulatory cell function and promotes anti-tumor immunity
7
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