Interaction network and enrichment analysis of genes upregulated in FOXP3 FOXP3 2T>C(mut)
Canned Analysis
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General Information
AccessionDCA00036490
TitleInteraction network and enrichment analysis of genes upregulated in FOXP3 FOXP3 2T>C(mut)
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between FOXP3 FOXP3 2T>C(mut) cells and control cells in the CD4+ T effector cells, resting phase cell type.
Analysis URLhttp://genemania.org/#/search/human/GNLY|IFNG|CCL5|HSPA8|CCL4L1|RNU1-1|TFRC|CCND2|HLA-DRB3|HLA-DRB4|JUN|HLA-DQA1|CCL1|FLNA|CCL3L3|NKG7|CCL3|HLA-DPB1|MT2A|HLA-DPA1|MAL|HLA-C|BIRC3|CORO1A|HLA-DRA
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1054
Cell TypeCD4+ T effector cells, resting phase
Gene Symbol (human)FOXP3
Gene Symbol (mouse)Foxp3
Organismhuman
Perturbation TypeFOXP3 2T>C(mut)
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1008441, GSM1008443, GSM1008445
Perturbed SamplesGSM1008444, GSM1008447, GSM1008449
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE41087
Gene Expression Omnibus
Expression data between FOXP3 wild type and 2T>C(mut)
14
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