Interaction network and enrichment analysis of genes downregulated in FOXP3 FOXP3 2T>C(mut)
Canned Analysis
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General Information
AccessionDCA00036491
TitleInteraction network and enrichment analysis of genes downregulated in FOXP3 FOXP3 2T>C(mut)
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between FOXP3 FOXP3 2T>C(mut) cells and control cells in the CD4+ T effector cells, 72h after antiCD3 and antiCD28 stimulation cell type.
Analysis URLhttp://genemania.org/#/search/human/CCL1|CCL4L1|GZMB|IFNG|GAPDH|RNU1-1|TUBB|HIST1H2BM|SDC4|NKG7|CCL4|CCL3|RDH10|HSP90AB1|CCL3L3|TFRC|HIST1H1B|HSPA8|IL2RA|SRSF1|LDHA|DUSP6|HIST1H4C|GZMA|MAT2A
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1055
Cell TypeCD4+ T effector cells, 72h after antiCD3 and antiCD28 stimulation
Gene Symbol (human)FOXP3
Gene Symbol (mouse)Foxp3
Organismhuman
Perturbation TypeFOXP3 2T>C(mut)
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1008440, GSM1008442
Perturbed SamplesGSM1008446, GSM1008448
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE41087
Gene Expression Omnibus
Expression data between FOXP3 wild type and 2T>C(mut)
14
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