Interaction network and enrichment analysis of genes downregulated in CD70 transgene
Canned Analysis
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General Information
AccessionDCA00036533
TitleInteraction network and enrichment analysis of genes downregulated in CD70 transgene
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between CD70 transgene cells and control cells in the CD71+ bone marrow cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Snca|Hmox1|Mrc1|Cd163|Ccr3|Cd5l|Vcam1|Hpgd|S100a9|Trf|Retnlg|Mmp8|Axl|Fcna|S100a8|Lcn2|Cd68|Cxcr2|Marcks|C1qc|Ear2|Cfp|Spic|Il1f9|Lpl
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1109
Cell TypeCD71+ bone marrow cells
Gene Symbol (human)CD70
Gene Symbol (mouse)Cd70
Organismmouse
Perturbation Typetransgene
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM562023, GSM562024, GSM562025
Perturbed SamplesGSM562026, GSM562027, GSM562028
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE22656
Gene Expression Omnibus
Expression data from CD71+ cells from the bone marrow of WT, CD70TG, IFNg-/- and CD70TG*IFNg-/- mice.
14
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