Interaction network and enrichment analysis of genes downregulated in IRAK4 IRAK4 kinase deficient mutant
Canned Analysis
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General Information
AccessionDCA00036577
TitleInteraction network and enrichment analysis of genes downregulated in IRAK4 IRAK4 kinase deficient mutant
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between IRAK4 IRAK4 kinase deficient mutant cells and control cells in the bone-marrow derived macrophages cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Saa3|Fat1|Lhfp|Gm13430|Gpc1|Cat|Gm19579|Senp3|Mat2a|Cdh11|Pf4|Mff|Colec12|Phldb2|LOC100505062|Zbtb18|Cd274|Abracl|Ppp1cb|Dusp22|Bgn|Ctgf|Lcn2|Lsm14b|Gm3601
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1131
Cell Typebone-marrow derived macrophages
Gene Symbol (human)IRAK4
Gene Symbol (mouse)Irak4
Organismmouse
Perturbation TypeIRAK4 kinase deficient mutant
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM229589, GSM229590
Perturbed SamplesGSM229595, GSM229596
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE9037
Gene Expression Omnibus
response to LPS of WT and IRAK4 kinase dead mouse bone marrow macrophages
7
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