Interaction network and enrichment analysis of genes downregulated in BRCA1 stable BRCA1 transfection of BRCA1-null cells
Canned Analysis
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General Information
AccessionDCA00036591
TitleInteraction network and enrichment analysis of genes downregulated in BRCA1 stable BRCA1 transfection of BRCA1-null cells
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between BRCA1 stable BRCA1 transfection of BRCA1-null cells cells and control cells in the HCC1937 cell type.
Analysis URLhttp://genemania.org/#/search/human/FGFBP1|MAL2|RARRES1|IL1R2|CALB2|BTBD16|ZFP42|HORMAD1|KLK8|KLK7|IL20RB|GATM|UCA1|S100A6|ANXA1|ARL14|NEURL1|TMEM154|SUN3|ANXA3|RAB12|CALHM3|IRX2|ANXA10|AKR1B1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1137
Cell TypeHCC1937
Gene Symbol (human)BRCA1
Gene Symbol (mouse)Brca1
Organismhuman
Perturbation Typestable BRCA1 transfection of BRCA1-null cells
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM764323, GSM764324, GSM764325
Perturbed SamplesGSM764320, GSM764321, GSM764322
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE30821
Gene Expression Omnibus
Integration of BRCA1-mediated miRNA and mRNA signatures reveal miR-146a, miR-99b and miR-205 regulation of the TRAF2 and NFkB pathways (mRNA dataset)
7
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