Interaction network and enrichment analysis of genes downregulated in IFNAR2 KO
Canned Analysis
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General Information
AccessionDCA00036593
TitleInteraction network and enrichment analysis of genes downregulated in IFNAR2 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between IFNAR2 KO cells and control cells in the bone-marrow derived macrophages cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Fcgr4|Slamf9|Ifitm3|Lgals3bp|Rsad2|Eif2ak2|Ly6e|Fpr2|AI607873|Cd274|Isg15|Cd72|Plagl2|Nmt1|Tmem184b|Ly6a|Ckb|Serp1|Cxcl9|Igtp|Ppp1r18|Siglec1|H2-T23|Ebi3|Usp18
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1139
Cell Typebone-marrow derived macrophages
Gene Symbol (human)IFNAR2
Gene Symbol (mouse)Ifnar2
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1111106, GSM1111107
Perturbed SamplesGSM1111108, GSM1111109
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE45632
Gene Expression Omnibus
Differential induction of TLR3-dependent innate immune signaling by closely related parasite species_I
7
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