Interaction network and enrichment analysis of genes upregulated in IRF7 stable IRF7 transfection (pMSCV)
Canned Analysis
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General Information
AccessionDCA00036600
TitleInteraction network and enrichment analysis of genes upregulated in IRF7 stable IRF7 transfection (pMSCV)
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between IRF7 stable IRF7 transfection (pMSCV) cells and control cells in the 4T1.2 cell type.
Analysis URLhttp://genemania.org/#/search/human/Mmp3|Ifi27|Lgals3bp|Ifitm3|Tuba1c|Apol9b|Tm4sf1|Bst2|Rtp4|Lgals3|Mif|Hmga1|Myl6|Wfdc2|Cox6a1|Oas1f|Psmd3|Ndufb9|Tnfrsf12a|Ran|Ifi202b|Isg15|Pgam1|Tnfaip2|Clic1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1146
Cell Type4T1.2
Gene Symbol (human)IRF7
Gene Symbol (mouse)Irf7
Organismhuman
Perturbation Typestable IRF7 transfection (pMSCV)
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM928616, GSM928617, GSM928618
Perturbed SamplesGSM928619, GSM928620, GSM928621
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE37828
Gene Expression Omnibus
Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape mechanisms
7
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