Interaction network and enrichment analysis of genes upregulated in SMAD3 KO
Canned Analysis
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General Information
AccessionDCA00036634
TitleInteraction network and enrichment analysis of genes upregulated in SMAD3 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between SMAD3 KO cells and control cells in the white adipose tissue cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Clu|Lcn5|Gpx5|Lcn8|Lcn2|Gm6792|Spink8|BC094435|Cuzd1|Crip1|Ucp1|Slc38a5|Adam7|Gpx3|Pebp1|Mfge8|Rnase10|Cidea|Cox8b|Ces5a|Chchd10|Rps26|Aco2|Kxd1|Eef1a1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1159
Cell Typewhite adipose tissue
Gene Symbol (human)SMAD3
Gene Symbol (mouse)Smad3
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM707747, GSM707748
Perturbed SamplesGSM707751, GSM707752
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE28598
Gene Expression Omnibus
TGF-beta/Smad3 signaling blockade effect on white adipose tissue
7
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