Interaction network and enrichment analysis of genes downregulated in XIAP DEPLETION -Late passage
Canned Analysis
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General Information
AccessionDCA00036655
TitleInteraction network and enrichment analysis of genes downregulated in XIAP DEPLETION -Late passage
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between XIAP DEPLETION -Late passage cells and control cells in the HCT116 colon cancer cells cell type.
Analysis URLhttp://genemania.org/#/search/human/SAT1|SLC38A2|ND2|DDIT4|SNHG8|CEBPB|ERRFI1|DCAF6|RPL13A|RPL13AP5|IER3|TPT1|ASS1|SNHG5|RPL30|COX1|GADD45A|RPL36A|SH3KBP1|EEF2|ATF4|RPL4|EEF1G|KRT18|EEF1A1P9
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1171
Cell TypeHCT116 colon cancer cells
Gene Symbol (human)XIAP
Gene Symbol (mouse)Xiap
Organismhuman
Perturbation TypeDEPLETION -Late passage
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM294818, GSM294819
Perturbed SamplesGSM294810, GSM294811, GSM294812, GSM294813
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11618
Gene Expression Omnibus
X-linked inhibitor of apoptosis XIAP depletion effect on a colorectal cancer cell line
14
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