Interaction network and enrichment analysis of genes upregulated in ESR1 L540Q point mutation
Canned Analysis
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General Information
AccessionDCA00036688
TitleInteraction network and enrichment analysis of genes upregulated in ESR1 L540Q point mutation
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between ESR1 L540Q point mutation cells and control cells in the MDA-MB-231 human mammary tumor cells cell type.
Analysis URLhttp://genemania.org/#/search/human/RPL8|HSP90AB1|MT1X|ODC1|HPCAL1|MT1E|RPL3|ACTB|FTH1P5|LOC100505584|MT1H|TUBB|CEBPB|CORO1C|ALDOA|ATF4|HMGB3|ENO1|PABPC1|CYC1|RPL34|SLC25A3|TFRC|MIF|MT2A
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorXavier
CREEDS IDgene:1193
Cell TypeMDA-MB-231 human mammary tumor cells
Gene Symbol (human)ESR1
Gene Symbol (mouse)Esr1
Organismhuman
Perturbation TypeL540Q point mutation
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM16943, GSM18491
Perturbed SamplesGSM18496, GSM18497
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1045
Gene Expression Omnibus
Estrogen receptor alpha L540Q mutation effect on gene induction by estradiol: time course
7
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