Interaction network and enrichment analysis of genes downregulated in SIN3A knock-down (with LIF agent treatment)
Canned Analysis
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General Information
AccessionDCA00036773
TitleInteraction network and enrichment analysis of genes downregulated in SIN3A knock-down (with LIF agent treatment)
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between SIN3A knock-down (with LIF agent treatment) cells and control cells in the MCF7 cell type.
Analysis URLhttp://genemania.org/#/search/human/DCAF6|COX2|HMGN2|COX1|KRT18|ND2|NGFRAP1|MIR21|TMSB4XP8|SH3KBP1|GTF3C6|HIST1H2BK|HSPB1|S100A16|ADI1|NDUFA1|CKMT1A|NDUFB9|C12orf57|RPL36A|ANP32B|UFC1|SNRPG|PHB2|TRMT112
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsolomoniyi
CREEDS IDgene:1249
Cell TypeMCF7
Gene Symbol (human)SIN3A
Gene Symbol (mouse)Sin3a
Organismhuman
Perturbation Typeknock-down (with LIF agent treatment)
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM873554, GSM873557
Perturbed SamplesGSM873559, GSM873563
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE35696
Gene Expression Omnibus
Leukemia inhibitory factor effect on Sin3a-silenced MCF7 breast cancer cell line
21
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