Interaction network and enrichment analysis of genes downregulated in COMMD3-BMI1 KD
Canned Analysis
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General Information
AccessionDCA00036843
TitleInteraction network and enrichment analysis of genes downregulated in COMMD3-BMI1 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between COMMD3-BMI1 KD cells and control cells in the DAOY medulloblastoma cells cell type.
Analysis URLhttp://genemania.org/#/search/human/RPS2|RPL34|EEF1B2|FAU|IFITM3|RPS3|SLC25A5|RPS29|RPL13A|RPS8|RPL8|IFITM2|HNRNPA1P10|RPS4X|MRFAP1|ID1|RPS14P3|H3F3AP4|RPS13|RPL3|RPL36A|RPLP0P6|TMSB4XP8|RPL30|RPL13AP5
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:129
Cell TypeDAOY medulloblastoma cells
Gene Symbol (human)COMMD3-BMI1
Gene Symbol (mouse)Bmi1
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM182018, GSM182019, GSM182020
Perturbed SamplesGSM182006, GSM182007, GSM182008
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE7578
Gene Expression Omnibus
Transcriptional regulators Bmi-1 and Mel-18 depletion effect on medulloblastoma cell line
21
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