Interaction network and enrichment analysis of genes downregulated in IGF1 KO
Canned Analysis
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General Information
AccessionDCA00036901
TitleInteraction network and enrichment analysis of genes downregulated in IGF1 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between IGF1 KO cells and control cells in the vestibular organ, day E18.5 cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Col10a1|Hbb-bt|Hba-a2|Ibsp|Col1a2|Col1a1|Col11a1|Spp1|Col9a1|Malat1|Ucma|Igf1|Sparc|Matn1|Col2a1|Hbb-b2|Acan|Fmod|Col3a1|Comp|Clec3a|Mmp13|Lect1|C1qtnf3|Panx3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1318
Cell Typevestibular organ, day E18.5
Gene Symbol (human)IGF1
Gene Symbol (mouse)Igf1
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1589481, GSM1589482, GSM1589483
Perturbed SamplesGSM1589478, GSM1589479, GSM1589480
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE65202
Gene Expression Omnibus
Gene expression study of developing mammalian vestibular organ of wild type and Insulin-Like Growth Factor I deficient mice using Affymetrix whole tra...
21
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