Interaction network and enrichment analysis of genes upregulated in HNF4A KD
Canned Analysis
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General Information
AccessionDCA00036972
TitleInteraction network and enrichment analysis of genes upregulated in HNF4A KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between HNF4A KD cells and control cells in the hepatic differentiated from ES cell cell type.
Analysis URLhttp://genemania.org/#/search/human/DLK1|IFITM3|GABRP|DCAF6|SH3KBP1|COX2|IFITM2|EGFL6|TIMP1|VTCN1|GJA1|ND2|PPAP2B|INS-IGF2|COL15A1|COL5A1|SERPINF1|OLFML3|MATN2|COL6A3|SNAI2|HMGN3|MAN1A1|CTHRC1|IGFBP3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1357
Cell Typehepatic differentiated from ES cell
Gene Symbol (human)HNF4A
Gene Symbol (mouse)Hnf4a
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM624094, GSM624095, GSM624096
Perturbed SamplesGSM624098, GSM624099, GSM624100
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE25417
Gene Expression Omnibus
HNF4A deficiency effect on embryonic stem cell model of hepatocyte differentiation
7
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