Interaction network and enrichment analysis of genes downregulated in DDIT3 knock-out (treated with 2 ug/ml tunicamycin for 4 hours)
Canned Analysis
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General Information
AccessionDCA00037013
TitleInteraction network and enrichment analysis of genes downregulated in DDIT3 knock-out (treated with 2 ug/ml tunicamycin for 4 hours)
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between DDIT3 knock-out (treated with 2 ug/ml tunicamycin for 4 hours) cells and control cells in the embryonic fibroblasts cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Ddit3|Cxcl5|Plac8|Hk1|S100a4|Htra1|Cxcl1|Cap1|Lpp|Sqstm1|Bsg|Twist2|Hspa9|Rpl8|Tpi1|Trib3|Arhgdib|Ier3|Atpif1|Ncl|Cct7|Gadd45a|Rpl36|Arl6ip1|Ldha
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorsolomoniyi
CREEDS IDgene:1387
Cell Typeembryonic fibroblasts
Gene Symbol (human)DDIT3
Gene Symbol (mouse)Ddit3
Organismmouse
Perturbation Typeknock-out (treated with 2 ug/ml tunicamycin for 4 hours)
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM37661, GSM37662, GSM37663, GSM37664
Perturbed SamplesGSM37665, GSM37666, GSM37667, GSM37668
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2082
Gene Expression Omnibus
Transcription factor CHOP null mutation effect on fibroblasts subjected to ER stress: time course
21
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