Interaction network and enrichment analysis of genes downregulated in KLF5 KO
Canned Analysis
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General Information
AccessionDCA00037065
TitleInteraction network and enrichment analysis of genes downregulated in KLF5 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between KLF5 KO cells and control cells in the LSK cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Rn18s|Mir703|Vpreb1|Prf1|Rps11|AY036118|B2m|Rpl18a|Rpl39|Rpl37|Gas5|Stmn1|Ctla2a|Rpl34-ps1|Rn28s1|0610010B08Rik|Gm10012|Rpl17|Tpt1|Gm12191|Rnf7|Tmsb10|Gm10925|Rps17|Malat1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1427
Cell TypeLSK cells
Gene Symbol (human)KLF5
Gene Symbol (mouse)Klf5
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1071463, GSM1071464, GSM1071465, GSM1071466, GSM1071467, GSM1071468
Perturbed SamplesGSM1071458, GSM1071459, GSM1071460, GSM1071461, GSM1071462
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE43806
Gene Expression Omnibus
Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated membrane Beta1/Beta2-integrin expression
7
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