Interaction network and enrichment analysis of genes upregulated in DGCR8 KO
Canned Analysis
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General Information
AccessionDCA00037128
TitleInteraction network and enrichment analysis of genes upregulated in DGCR8 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between DGCR8 KO cells and control cells in the ES cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Vim|Ifitm1|Mov10|Scpep1|Nanog|Mir92-1|Mir18|Mir20a|Gdf3|Mir19b-1|Cth|9530068E07Rik|Ckb|Cd81|Stmn1|Ifitm3|Rbm3|Nr0b1|Sparc|Mt2|Pdgfc|Mdh2|Mir23b|Psap|Rny3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1456
Cell TypeES cells
Gene Symbol (human)DGCR8
Gene Symbol (mouse)Dgcr8
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM424460, GSM424461, GSM424462
Perturbed SamplesGSM424463, GSM424464, GSM424465
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE16923
Gene Expression Omnibus
Expression data from wild-type, Dgcr8 knockout and Dicer knockout ES cells
14
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