Interaction network and enrichment analysis of genes downregulated in DICER1 KO
Canned Analysis
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General Information
AccessionDCA00037129
TitleInteraction network and enrichment analysis of genes downregulated in DICER1 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between DICER1 KO cells and control cells in the ES cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Pla2g1b|Rplp0|Srm|Peg10|Slc38a4|Slc38a2|Dnmt3l|Pabpc1|Rs5-8s1|Zfp57|Stab1|Odc1|Trim28|Ifitm3|Gart|Ldha|Erdr1|Hmga1-rs1|Utf1|Dnmt3b|Slc25a4|Cirh1a|Nutf2-ps1|Mid1|Pim1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1457
Cell TypeES cells
Gene Symbol (human)DICER1
Gene Symbol (mouse)Dicer1
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM424460, GSM424461, GSM424462
Perturbed SamplesGSM424466, GSM424467, GSM424468
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE16923
Gene Expression Omnibus
Expression data from wild-type, Dgcr8 knockout and Dicer knockout ES cells
14
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