Interaction network and enrichment analysis of genes downregulated in AHR low-affinity mutant
Canned Analysis
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General Information
AccessionDCA00037139
TitleInteraction network and enrichment analysis of genes downregulated in AHR low-affinity mutant
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between AHR low-affinity mutant cells and control cells in the bone marrow derived mast cells (BMMCs) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Ifitm2|Mt1|Cma1|Csf2rb2|Ly6a|Ubb|Rps20|Rgs1|Dusp1|Fos|Rpl41|Avil|Scin|Ppa1|Rplp1|Fcer1g|Laptm5|Rpl35a|Cd53|Rpl27|Rps4x|Sqstm1|Errfi1|Rps21|Junb
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1467
Cell Typebone marrow derived mast cells (BMMCs)
Gene Symbol (human)AHR
Gene Symbol (mouse)Ahr
Organismmouse
Perturbation Typelow-affinity mutant
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1089253, GSM1089254, GSM1089255
Perturbed SamplesGSM1089247, GSM1089248, GSM1089249
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE44715
Gene Expression Omnibus
Mast cell expression data from murine aryl hydrocarbon receptor (AhR) null, AhR_d and normal control mice
14
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