Interaction network and enrichment analysis of genes downregulated in ATF6 tamoxifen-induced activation
Canned Analysis
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General Information
AccessionDCA00037147
TitleInteraction network and enrichment analysis of genes downregulated in ATF6 tamoxifen-induced activation
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between ATF6 tamoxifen-induced activation cells and control cells in the heart left ventricle cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Actn2|Ndufb10|Eef1a2|Ndufv3|Cox4i1|Ech1|Bsg|Chchd10|Hspb7|Rpl28|Eno3|Mybpc3|Tnni3|Sdhb|Cox7a1|Crip2|Gapdh|Cox8b|Cox6a2|Pgam2|Uqcr11|Myl3|Actc1|Hspb6|Hrc
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1473
Cell Typeheart left ventricle
Gene Symbol (human)ATF6
Gene Symbol (mouse)Atf6
Organismmouse
Perturbation Typetamoxifen-induced activation
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM206351, GSM206352, GSM206353
Perturbed SamplesGSM205922, GSM205923, GSM206335
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE8322
Gene Expression Omnibus
Transgenic model of selective ATF6 activation: heart
7
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