Interaction network and enrichment analysis of genes downregulated in TSC1 KO
Canned Analysis
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General Information
AccessionDCA00037169
TitleInteraction network and enrichment analysis of genes downregulated in TSC1 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between TSC1 KO cells and control cells in the FACS purified YFP+ muscle stem cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Rps5|Gnb2l1|Fam132b|Rplp0|Rps15|Slc39a14|Rpl3|Fau|Rpl18|Use1|Rpl19|Btg1|Rpl18a|Rplp1|Tnfaip6|Bdkrb1|Nppc|S1pr3|Snord104|Rpl38|Slc38a2|Rps10|Chrdl2|1810011O10Rik|Nrep
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1483
Cell TypeFACS purified YFP+ muscle stem cells
Gene Symbol (human)TSC1
Gene Symbol (mouse)Tsc1
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1338079, GSM1338080, GSM1338081, GSM1338082, GSM1338083
Perturbed SamplesGSM1338090, GSM1338091
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE55490
Gene Expression Omnibus
mTORC1 controls the systemically-induced adaptive regulation of stem cell quiescence into GAlert
21
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