Interaction network and enrichment analysis of genes downregulated in PBRM1 KO
Canned Analysis
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General Information
AccessionDCA00037183
TitleInteraction network and enrichment analysis of genes downregulated in PBRM1 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between PBRM1 KO cells and control cells in the Clear-cell renal cell carcinoma tumor (VHL inactivated) cell type.
Analysis URLhttp://genemania.org/#/search/human/IGHV4-31|RPS4Y1|ALDH8A1|GPX3|UBD|DEGS1|CXCL9|CXCL10|NAT8|TSPAN1|PCK1|HMOX1|TNFSF10|HP|H3F3AP4|RARRES3|CP|MIF|NGFRAP1|NAT8B|HLA-DQA2|SAT1|SLPI|SELM|LOC102659288
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:1494
Cell TypeClear-cell renal cell carcinoma tumor (VHL inactivated)
Gene Symbol (human)PBRM1
Gene Symbol (mouse)Pbrm1
Organismhuman
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM904989, GSM905002, GSM905009, GSM905014, GSM905020, GSM905023, GSM905029, GSM905034
Perturbed SamplesGSM904991, GSM904994, GSM904996, GSM905007, GSM905012, GSM905022, GSM905026, GSM905027, GSM905031, GSM905036, GSM905041, GSM905044
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE36895
Gene Expression Omnibus
Clear-cell renal cell carcinoma tumors and tumorgrafts deficient for tumor suppressor BAP1 or PBRM1
21
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