Interaction network and enrichment analysis of genes downregulated in DICER1 KO
Canned Analysis
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General Information
AccessionDCA00037197
TitleInteraction network and enrichment analysis of genes downregulated in DICER1 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between DICER1 KO cells and control cells in the Sarcoma cell line cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Mgp|Crabp1|Postn|S100a4|Dkk2|Col1a1|Ecm1|Loxl3|Ifi27l2a|Tmsb4x|Pqlc3|Pdgfrl|Gvin1|1110038B12Rik|2410006H16Rik|Lgals3|Timp3|Igfbp6|Tagln|Penk|1500012F01Rik|Pdk4|Bhlhb9|Rpl22l1|C1s1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1501
Cell TypeSarcoma cell line
Gene Symbol (human)DICER1
Gene Symbol (mouse)Dicer1
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1079827, GSM1079828, GSM1079829
Perturbed SamplesGSM1079830, GSM1079831, GSM1079832
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE44162
Gene Expression Omnibus
Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts [3p arrays]
7
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