Interaction network and enrichment analysis of genes downregulated in STAT1 KO
Canned Analysis
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General Information
AccessionDCA00037213
TitleInteraction network and enrichment analysis of genes downregulated in STAT1 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between STAT1 KO cells and control cells in the bone marrow macrophages (BMMs) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Ly6e|Lgals3bp|Oasl2|Cxcl10|Ly6a|Trim30a|Ifit3|H2-K1|Rtp4|H2-D1|Usp18|AI607873|Lgals9|H2-Q6|Siglec1|Ccl3|Ifi44|Apoe|Ifitm3|Mnda|Rsad2|Rnf213|Cdkn1a|Ifi203|Oas1a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1519
Cell Typebone marrow macrophages (BMMs)
Gene Symbol (human)STAT1
Gene Symbol (mouse)Stat1
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1190948, GSM1190952, GSM1190956
Perturbed SamplesGSM1190947, GSM1190951, GSM1190955
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE48970
Gene Expression Omnibus
Contribution of the STAT1alpha and STAT1beta isoforms to IFN-gamma mediated innate immunity
21
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