Interaction network and enrichment analysis of genes downregulated in HDAC3 Intestinal Epithelial Cells specific deletion of HDAC3
Canned Analysis
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General Information
AccessionDCA00037265
TitleInteraction network and enrichment analysis of genes downregulated in HDAC3 Intestinal Epithelial Cells specific deletion of HDAC3
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between HDAC3 Intestinal Epithelial Cells specific deletion of HDAC3 cells and control cells in the Intestinal Epithelial Cells from large intestine cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Sycn|Retnlb|Mptx1|Hpgd|Mep1a|Gsdmc2|Mt2|Reg4|Saa2|Aoc1|Slc10a2|Aldh1a1|Slc37a2|Gm9994|Guca2a|Pigr|Hist1h1c|Slc26a3|Tmigd1|Cdhr5|Clca4|Sct|Papss2|Tmsb4x|Hsd11b2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1550
Cell TypeIntestinal Epithelial Cells from large intestine
Gene Symbol (human)HDAC3
Gene Symbol (mouse)Hdac3
Organismmouse
Perturbation TypeIntestinal Epithelial Cells specific deletion of HDAC3
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1215249, GSM1215250, GSM1215251
Perturbed SamplesGSM1215252, GSM1215253, GSM1215254
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE50189
Gene Expression Omnibus
Regulation of gene expression in IECs by HDAC3 under germ-free conditions
7
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