Interaction network and enrichment analysis of genes downregulated in IL6 anti-IL6 monoclonal antibody, neutralization
Canned Analysis
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General Information
AccessionDCA00037279
TitleInteraction network and enrichment analysis of genes downregulated in IL6 anti-IL6 monoclonal antibody, neutralization
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between IL6 anti-IL6 monoclonal antibody, neutralization cells and control cells in the Xenograft tumors from DU145 cell type.
Analysis URLhttp://genemania.org/#/search/human/FGG|BPIFA1|IFITM3|FGB|SPTSSA|NNMT|ND2|IFITM2|SH3KBP1|EFNA1|DMBT1|CEBPB|LDHA|DCAF6|TP53INP2|MUC1|GPX3|KRT18|IGFBP3|HMGB3|SQRDL|PPA1|C5|SFTPB|SAT1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1555
Cell TypeXenograft tumors from DU145
Gene Symbol (human)IL6
Gene Symbol (mouse)Il6
Organismhuman
Perturbation Typeanti-IL6 monoclonal antibody, neutralization
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1536778, GSM1536779, GSM1536780
Perturbed SamplesGSM1536775, GSM1536776, GSM1536777
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE62941
Gene Expression Omnibus
Inhibition of Interleukin-6 (IL-6) Signaling and Tumor Growth by a Human Neutralizing Anti-IL-6 Antibody with a Prolonged Half-Life
21
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