Interaction network and enrichment analysis of genes downregulated in KLF1 KO
Canned Analysis
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General Information
AccessionDCA00037293
TitleInteraction network and enrichment analysis of genes downregulated in KLF1 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between KLF1 KO cells and control cells in the primitive erythroid precursors cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Ahsp|Hemgn|Hbb-bs|Slc25a37|Alad|Anp32b|Ermap|Klf1|Rpl39-ps|Mrfap1|Rps26|Rps27a|Hba-x|Hbb-y|Cacybp|Eef1a1|Mt2|Oaz1|Gm13430|Gm12191|Apob|Rpl38|Rps29|Chchd2|Hba-a2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormaroulisv
CREEDS IDgene:1562
Cell Typeprimitive erythroid precursors
Gene Symbol (human)KLF1
Gene Symbol (mouse)Klf1
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM893168, GSM893169, GSM893170, GSM893171, GSM893175, GSM893176, GSM893177, GSM893178
Perturbed SamplesGSM893172, GSM893173, GSM893174
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE36427
Gene Expression Omnibus
KLF1, KLF2 and c-myc control a regulatory network essential for embryonic erythropoiesis
7
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