Interaction network and enrichment analysis of genes downregulated in PPARG V290M dominant negative mutation
Canned Analysis
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General Information
AccessionDCA00037457
TitleInteraction network and enrichment analysis of genes downregulated in PPARG V290M dominant negative mutation
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between PPARG V290M dominant negative mutation cells and control cells in the Primary aortic endothelial cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Spp1|Pla2g16|Rpl38|LOC100504128|Gm5805|Sepp1|Fth1|E430024C06Rik|Cat|Cxcl13|Tmbim6|Idh1|Egr1|Rpl39-ps|Rps3a2|Lbp|Gm12191|Igfbp3|Tmsb4x|Gm3601|Kxd1|Rpl31-ps17|Fabp5|Gm4076|Adipoq
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:1726
Cell TypePrimary aortic endothelial cells
Gene Symbol (human)PPARG
Gene Symbol (mouse)Pparg
Organismmouse
Perturbation TypeV290M dominant negative mutation
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM299778, GSM299779, GSM299780
Perturbed SamplesGSM299781, GSM299782, GSM299783
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE11870
Gene Expression Omnibus
Aortic endothelial cell response to dominant negative PPAR gamma expression in vitro
7
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