Interaction network and enrichment analysis of genes upregulated in BMPR2 dominant negative mutation BMPR2delx4+
Canned Analysis
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General Information
AccessionDCA00037460
TitleInteraction network and enrichment analysis of genes upregulated in BMPR2 dominant negative mutation BMPR2delx4+
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between BMPR2 dominant negative mutation BMPR2delx4+ cells and control cells in the lung cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Ear2|Ear12|S100a8|Chil3|Ear3|S100a9|Chil4|Ctss|Retnla|Lyz2|Gm3601|Ccl6|Tyrobp|Ctsd|Lgals3|Saa3|Cxcl15|S100g|Fabp5|Lamp3|Cyba|Lrg1|Sftpd|Slc34a2|Nme2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:1727
Cell Typelung
Gene Symbol (human)BMPR2
Gene Symbol (mouse)Bmpr2
Organismmouse
Perturbation Typedominant negative mutation BMPR2delx4+
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM118653, GSM118658
Perturbed SamplesGSM119286, GSM119287
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE5255
Gene Expression Omnibus
Bone morphogenic protein receptor 2 inactivation in smooth muscle effect on the lung: time course
7
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