Interaction network and enrichment analysis of genes downregulated in BMPR2 R899X mutation
Canned Analysis
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General Information
AccessionDCA00037475
TitleInteraction network and enrichment analysis of genes downregulated in BMPR2 R899X mutation
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between BMPR2 R899X mutation cells and control cells in the pulmonary vascular microendothelial cells (PMVEC) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Folh1|Serpina3n|Serping1|Gstm1|Ly6a|Dgka|Xist|Osr1|1700007K13Rik|Ces2e|Mdm2|Nid1|Gclc|Irgm1|Tgtp2|Igfbp3|Rhoj|Scn3b|Sulf2|Thbs1|Figf|Cxcl13|Ivl|Ccl7|Ctla2a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:1736
Cell Typepulmonary vascular microendothelial cells (PMVEC)
Gene Symbol (human)BMPR2
Gene Symbol (mouse)Bmpr2
Organismmouse
Perturbation TypeR899X mutation
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM693825, GSM693826
Perturbed SamplesGSM693829, GSM693830
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE28043
Gene Expression Omnibus
Pulmonary vascular microendothelial cell response to mutations in type 2 receptor for the bone morphogenetic protein signaling pathway, BMPR2
14
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