Interaction network and enrichment analysis of genes upregulated in CFTR F508 CFTR mutation
Canned Analysis
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General Information
AccessionDCA00037498
TitleInteraction network and enrichment analysis of genes upregulated in CFTR F508 CFTR mutation
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between CFTR F508 CFTR mutation cells and control cells in the CFBE41o- cell type.
Analysis URLhttp://genemania.org/#/search/human/KRT81|RPL21|HLA-B|TMSB4XP8|ISG15|ANXA8L1|HLA-A|HLA-C|EEF1A2|PPA1|NGFRAP1|C19orf33|RPL41|ADIRF|ND2|TIMP1|PGAM1|TPT1|TXNIP|UCA1|TSPAN1|PSME1|RBBP7|COX6B1|PSMA6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:1744
Cell TypeCFBE41o-
Gene Symbol (human)CFTR
Gene Symbol (mouse)Cftr
Organismhuman
Perturbation TypeF508 CFTR mutation
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM754987, GSM754988, GSM754989, GSM754990
Perturbed SamplesGSM754979, GSM754980, GSM754981, GSM754982
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE30439
Gene Expression Omnibus
Cystic fibrosis bronchial epithelial cells exposure to Pseudomonas aeruginosa PA01 biofilms
7
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