Interaction network and enrichment analysis of genes downregulated in TRAC Stimulation ( anti-α-chain (aVα2))
Canned Analysis
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General Information
AccessionDCA00037523
TitleInteraction network and enrichment analysis of genes downregulated in TRAC Stimulation ( anti-α-chain (aVα2))
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between TRAC Stimulation ( anti-α-chain (aVα2)) cells and control cells in the Thymocytes (CD4+CD8+ double positive) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Satb1|Hist1h2ao|Tpt1|LOC665506|Rps11|Rpl7|Cd164|Rps26|Rps27rt|Jund|Cd8b1|Tcf7|Rplp0|Rmnd5a|Rpl5|Hmha1|Lck|Cd4|Pabpc1|H2-T18|Ptms|Cdca7|Lbr|H3f3a|Rplp1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:1755
Cell TypeThymocytes (CD4+CD8+ double positive)
Gene Symbol (human)TRAC
Organismmouse
Perturbation TypeStimulation ( anti-α-chain (aVα2))
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM24449, GSM24452
Perturbed SamplesGSM24450, GSM24453
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1448
Gene Expression Omnibus
Thymocyte response to anti-T cell receptor antibody stimulation
14
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